ICSI allows many men with male factor infertility to create genetically-related children. It is performed as part of an IVF cycle, where a single sperm is inserted directly into the egg to allow fertilization.

Most times, the sperm required for ICSI are retrieved through the ejaculate. However, for some men with no sperm in the ejaculate, there is still a possibility of fathering children. The sperm can be retrieved directly from the testicles [TESE] or from the epididymis [MESA or PESA].

Intracytoplasmic Sperm Injection FAQ

What is the success rate of ICSI?

Fertilization rates and pregnancy success rates using ICSI are typically comparable to those using standard IVF without ICSI.

Years of follow-up on children conceived using ICSI have shown no increase in birth defects. There is some concern, however, that male offspring may have a slightly higher rate of infertility; however, this has not been demonstrated.