Follicle stimulating hormone (FSH) and luteinizing hormone (LH) are called gonadotropins. They are produced by the pituitary gland and governed by the hypothalamus. The hypothalamus manufactures gonadotropin-releasing hormone (GnRH), which signals the pituitary to increase or decrease the production of hormones including LH, estrogen, and FSH.

Medication containing FSH causes the ovaries to develop follicles. It is used in IVF (where numerous eggs are required) and in stimulated intrauterine insemination (IUI) cycles.

In IVF cycles, FSH is usually administered in combination with other fertility drugs, such as Lupron, Synarel, Buserelin, Cetrotide, or orgalutran. These products allow the specialist to precisely control follicular development and the timing of ovulation.

FSH/LH  FAQ

What is Pergonal?

Pergonal is the first FSH-containing product (menotropin [hMG]). It is a natural product extracted from the urine of postmenopausal women. After menopause, FSH levels increase dramatically because the ovaries have ceased to function. Pergonal contains equal amounts of FSH and LH and has traces of other contaminants.

What human-derived FSH products are available in Canada?

• Repronex
• Bravelle
• Menopur

What other FSH/LH products are available?

The following FSH products are manufactured using genetic recombinant cell technology, a process that produces pure FSH or pure LH identical to the human body with no contaminants:

• Gonal-F (pure FSH)
• Puregon (pure FSH)
• Luveris (pure LH)

What is the importance of LH?

The importance of LH is still under debate. Some specialists believe that small amounts of LH facilitate a better stimulation requiring less medication; others believe that pure FSH could have advantages, including improved embryo quality.

What are gonadtropins and when should they be administered?

Gonadotropins are FSH ± LH. They should only be administered by a physician thoroughly trained in their use and in the management of potential side effects. Dosage adjustments are made based upon follicular development, and side effects are avoided by closely monitoring the number of follicles and estradiol levels. Side effects associated with gonadotropins include ovarian hyperstimulation syndrome, multiple gestation, tubal pregnancies, and ovarian torsion.

How do I administer FSH, LH, or HMG?

Most patients either self-administer these products or get help from a friend or spouse. The majority of FSH preparations can be given subcutaneously, and some, including Gonal-F and Puregon, are available in a convenient pen applicator, which is easy to administer.

Where can I purchase FSH, LH or HMG?

You can purchase FSH, LH, or HMG at most pharmacies with a prescription. However, they often have to be ordered in.

PCRM has an on-site pharmacy which enables us to prescribe, counsel, and dispense all at one location for your convenience.