| TriO | NIPT only | FTS & PE only | |||
|---|---|---|---|---|---|
| Singleton | Twins | Standard NIPT (singleton or twins) | Standard NIPT + 8 Microdeletion Syndromes (singleton only) | ||
| First Trimester Screening Abdominal ultrasound: viability, growth, early anatomy, markers of chromosome differences (NT, FHR, DV, NB)* Maternal serum: PAPP-A and hCG | ✔ | ✔ | ✘ | ✘ | ✔ |
| Pre-Eclampsia Screening (maternal blood pressure, serum PlGF, PAPP-A, history questionnaire) | ✔ | ✔ | ✘ | ✘ | ✔ |
| NIPT: Chromosome differences -Trisomy 21 (Down syndrome), Trisomy 18, Trisomy 13 | ✔ | ✔ | ✔ | ✔ | ✘ |
| NIPT: Sex chromosome differences (X, XXY, XXX, XYY) | ✔ (optional) | Not available | ✔ (singleton only) | ✔ | ✘ |
| NIPT: Fetal sex(es) | ✔ (optional) | ✔ (optional) | ✔ | ✔ | ✘ |
| NIPT: Microdeletion Syndromes | ✔ 6 (optional) 22q11.2 del syndrome Cri-du-chat syndrome 1p36 deletion syndrome Prader-Willi syndrome Angelman syndrome Wolf-Hirschhorn syndrome | Not available | ✘ | ✔ 8 22q11.2 del syndrome Cri-du-chat syndrome 1p36 deletion syndrome Prader-Willi syndrome Angelman syndrome Wolf-Hirschhorn syndrome Jacobsen syndrome** Langer-Giedion syndrome** | ✘ |
| Cost (CAD- no tax) | $1000 | $1250*** | $650 | $950 | $650 |
