Preimplantation Genetic Testing (PGT)

Preimplantation Genetic Testing (PGT)

Preimplantation genetic testing (PGT) involves screening embryos for chromosome abnormalities before transferring them to the uterus. This can help reduce the odds of a genetic problem in the baby that might otherwise lead to a miscarriage or a failed in vitro fertilization (IVF) cycle. PGT is different from prenatal screening (e.g. NIPT, FTS, TRIO, SIPS) because those tests examine an existing pregnancy, usually after 10 weeks of gestation, while PGT helps to examine embryos before initiating conception and pregnancy.

The Benefits of Choosing PCRM for PGT

At our fertility clinics in Greater Vancouver, BC and Greater Edmonton, AB, you can always expect personalized care, no matter how advanced a treatment option is. Our team is committed to helping all aspiring parents find the approach that’s best for their specific reproductive needs.

Is PGT the Right Treatment for You?

Aspiring parents may choose PGT for a number of reasons:

  • They wish to screen embryos before transferring them in the hopes of choosing the one with the highest chance of success.
  • They have undergone standard IVF cycles that have been unsuccessful or resulted in miscarriages.
  • One partner carries an inherited chromosome rearrangement, such as a translocation or inversion.
  • They have a child with a genetic condition and would like to reduce the chance of inheritance for their future children.
  • They have a genetic condition or an increased risk of developing a genetic condition and would like to reduce the chance of inheritance for their future children.

The potential benefit of PGT for your specific needs is determined during the first consultation visit with your fertility specialist. If you would like more information about the benefits and limitations of PGT, you can call PCRM to make an appointment to talk to our genetic counselors.

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How PGT Works

PGT starts with the IVF process, where the egg is fertilized with sperm in the embryology lab. Five or six days after fertilization, a biopsy is performed, where a small sample of cells is removed from each embryo, frozen via vitrification, and sent off to a genetics lab, typically Cooper Genomics or Natera, for analysis. The embryos are kept frozen until genetic testing has been completed. The biopsied embryonic cells are tested for chromosomal abnormalities or genetic conditions. PGT results are ready about 1-2 weeks after biopsy.

Types of PGT

The different types of PGT include:

Evaluating an embryo’s chromosome makeup using PGT-A techniques helps to select the ones that have the correct number of chromosomes. Transferring these embryos may result in higher implantation and pregnancy rates and may help avoid miscarriage.

There are a number of different PGT-A platforms including array CGH (comparative genomic hybridization), SNP (single nucleotide polymorphism) array, and NGS (next-generation sequencing). Each technique ultimately performs the same task. All are highly effective, with accuracies of 97-99%.

For the majority of patients undergoing PGT at PCRM, the biopsied cells are sent to Cooper Genomics. Cooper Genomic’s PGT-A method is an NGS platform. The results provide highly accurate information for all 46 chromosomes.

Frequently Asked Questions About PGT

Choose PCRM for Preimplantation Genetic Testing (PGT) in Greater Vancouver and Edmonton

Serving British Columbia, Alberta, and Western Canada, PCRM is committed to giving aspiring parents their best chances of successfully having a child through IVF, which includes offering preimplantation genetic testing services. If you’re ready to take the next step towards becoming a parent, connect with us today for a genetic testing consultation.

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