1. Home
2. Resources
3. PCRM Blog
4. Your Guide to PGT-A: When Genetic Testing Can Help—and When It Might Not

Your Guide to PGT-A: When Genetic Testing Can Help—and When It Might Not

Preimplantation Genetic Testing for Aneuploidy (PGT-A) has become an increasingly common option in the world of assisted reproduction. Designed to screen embryos for chromosomal abnormalities, PGT-A can offer reassurance and guidance for many patients undergoing IVF. But as with any technology, it comes with both advantages and limitations—and it’s not the right choice for everyone.

At PCRM, our goal is to provide clear, evidence-based information to help you make informed decisions at every step of your fertility journey. Here's what you need to know about PGT-A: how it works, who it may benefit, and what to consider before proceeding.

What Is PGT-A?

PGT-A is a type of genetic testing performed on embryos created through in vitro fertilization (IVF). At the blastocyst stage (usually day 5 or 6), a few cells are gently biopsied from the embryo and sent to a specialized lab for analysis. The goal is to identify embryos with the correct number of chromosomes—called euploid embryos—and avoid transferring embryos with aneuploidies, or missing/extra chromosomes.

Chromosomal abnormalities are a major cause of IVF failure, miscarriage, and certain genetic conditions. PGT-A helps select embryos that are more likely to result in a healthy pregnancy.

Benefits of PGT-A

1. Improved Implantation Rates
   By transferring embryos with the correct number of chromosomes, PGT-A can increase the chance of successful implantation and reduce the likelihood of failed IVF cycles. According to CFAS, chromosomal screening can improve efficiency, particularly in patients with a history of multiple failed IVF attempts.

2. Reduced Risk of Miscarriage
   One of the most common causes of miscarriage is chromosomal abnormality. PGT-A may help reduce this risk by identifying embryos that are more genetically stable before implantation.

3. Shortened Time to Pregnancy
   When embryos are tested in advance, clinicians can confidently transfer a single, viable embryo. This approach may decrease the number of cycles required to achieve a pregnancy—saving both time and emotional stress.

4. Empowered Decision-Making
   PGT-A can provide valuable information for individuals or couples navigating difficult decisions—particularly those with a history of failed transfers or recurrent pregnancy loss.

   ---

Drawbacks and Considerations

1. It’s Not Always Necessary
   PGT-A is most often recommended for:

• Patients over the age of 35
• Those with recurrent pregnancy loss
• Patients with multiple failed IVF cycles

For younger patients or those undergoing their first IVF cycle, the benefits of PGT-A may be less clear. A recent position paper by the Canadian Fertility and Andrology Society (CFAS) emphasizes the importance of individualized care when considering genetic testing.

2. Additional Costs
   PGT-A adds to the overall cost of IVF treatment. While some extended health insurance plans may offer partial coverage for genetic testing, it is often an out-of-pocket expense in Canada. At PCRM, we provide transparent pricing and help you weigh cost vs. benefit in your unique case.

3. Risk of Embryo Damage
   Embryo biopsy is a delicate procedure, and while it is considered safe and well-established, there is a small risk of damage. That’s why it’s critical to have testing performed by an experienced embryology team, like the one at PCRM.

4. Mosaic Results and Uncertainty
   Sometimes, PGT-A results are less straightforward. If the analysis detects both normal and abnormal cells in the same sample, an embryo might receive a “mosaic” result. These cases can be more difficult to interpret and may result in complex decisions around embryo use. Current data suggests that many mosaic embryos can still result in healthy pregnancies, but the outcomes are less predictable.

5. Emotional and Ethical Considerations
   Choosing which embryos to transfer—or not to transfer—can be emotionally and ethically complex. It’s important to feel supported throughout this process, both medically and emotionally. At PCRM, we offer counselling services to help patients navigate these choices with clarity and care.

   ---

Should You Consider PGT-A?

The answer depends on your medical history, age, reproductive goals, and personal values. For some, PGT-A offers peace of mind and a higher chance of success. For others, it may add unnecessary cost or complexity. The best way to know is to talk with your fertility specialist and explore all available options.

We're Here to Help

At PCRM, we believe in personalized fertility care—not one-size-fits-all solutions. If you're wondering whether PGT-A is right for you, we’re here to guide you through the decision with evidence-based insights and compassionate support.

See all articles